Strengthening a community-engaged research partnership to promote diabetes self-management in Richmond

Dates: 7/1/16-6/30/17

Sponsor: VCU Council for Community Engagement

Principal Investigator: Briana Mezuk

Objectives: To conduct mixed-methods research on the challenges people face when participating in a diabetes class and the ways they overcome those challenges and to establish a Community Advisory Board.


Genetic, social, and developmental epidemiology of drug use disorders

Dates: 4/1/16 – 1/31/21

Sponsor: NIDA (2 R01-DA030005-06A1)

Principle Investigator: Kenneth Kendler

Co-investigator: Briana Mezuk

Objective: To understand the etiology, consequences, and causes of drug use disorders using data available on the entire population of Sweden.


Stress, self-regulatory behaviors, and diabetes disparities

Dates: 1/1/2016-12/31/2018

Sponsor: American Diabetes Association (1-16-ICTS-082)

Principal Investigator: Briana Mezuk

Objectives: To examine how stress exposure and stress reactivity contribute to the progression of metabolic risk among adult with pre-diabetes.


Depression, inflammation, and diabetes: Exploring shared etiopathology

Date: 8/1/2012 – 7/31/2016

Sponsor: National Institute of Mental Health (K01-MH093642-A1)

Principal Investigator: Briana Mezuk

Mentor: Kenneth Kendler

Objectives: To evaluate environmental and genetic contributions, and their interaction, of the relationship between major depression and type 2 diabetes in later adulthood; investigate the physiologic pathways, particularly immune function, linking depression and diabetes; and examine the influence of depressive symptoms on expression of immune-related genes and glucose metabolism.


Reducing ethnic group disparities in cardiovascular and mental health disorders (Project within the Center for Integrative Approaches to Health Disparities)

Date: 8/1/12 – 7/31/17

Sponsor: National Institute on Minority Health and Health Disparities (2P60-MD002249-06)

Principle Investigators: Ana Diez Roux, James S. Jackson

Co-Investigator: Briana Mezuk

Objectives: To examine how stress, poor health behaviors, and mental health contribute to disparities in cardiovascular disease and other conditions using existing data sources.




Understanding Health Disparities in the Progression of Type 2 Diabetes

Date: 9/1/2010 – 8/31/2015

Sponsor: National Institute on Minority Health and Health Disparities (R01-MD006085)

Principle Investigator: James S. Jackson

Consultant: Briana Mezuk

Objectives: To examine the interrelationships between stress, health behaviors, and depression in an accelerated longitudinal design by examining these relationships in three progressive groups of type 2 diabetes patients: pre-diabetes, newly onset diabetes; and poorly-controlled diabetes.


Frailty and depression: A latent trait analysis

Date: 7/1/13 – 6/30/15

Sponsor: National Institute of Aging (F31-AG044974-01A1)

Principal Investigator: Matthew Lohman

Primary Mentor: Briana Mezuk

Objective: To provide instruction in methodological and conceptual approaches of investigating comorbidity in later life; to provide training in the area of quantitative epidemiologic research; and to conduct mentored independent research on the interrelationships between depression and frailty.


Diabetes, depression, and the contextual environment: A multi-level analysis

Date: 3/18/2013 – 2/28/2015

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (R21-DK8356430-01A1)

Principal Investigator: Briana Mezuk

Objectives: To prospectively investigate the dynamic roles of the contextual environment, familial genetic risk, and their interplay on the development of comorbid type 2 diabetes and depression.


Stress reactivity and glycemia among African Americans at high risk for type 2 diabetes

Date: 8/1/12 – 12/31/13

Sponsor: AD Williams Fund, VCU Center for Advancing Translational Sciences

Principal Investigator: Briana Mezuk

Objective: To examine the role of stress exposure and biological stress reactivity as predictors of racial disparities in diabetes risk.


Examining the interrelationships between depression and metabolic disorders in later life

Date: 7/1/2012 – 6/30/2013

Sponsor: NIH Extramural Clinical Research Loan Repayment Program (Renewal)

Principal Investigator: Briana Mezuk

Mentor: Kenneth Kendler

Objectives: (1) Repayment of educational debt; (2) Research focused on parallel investigators of the epidemiologic links between depression and metabolic conditions in later life.


Depression, antidepressants, and frailty

Date: 8/1/2010 – 7/31/2012

Sponsor: National Institute for Child Health and Development, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar (K12-HD055881)

Principal Investigator: Jerome Strauss

Mentor: Kate Lapane

Fellow: Briana Mezuk

Objectives: To examine the bi-directional relationships between depression and frailty syndrome among older adults; evaluate whether physiologic markers mediate the relationship between depression and frailty; and assess whether antidepressants are associated with frailty independent of depression.


Suicide prevention across the lifespan for the Commonwealth of Virginia

Date: 3/1/12 – 7/31/12

Sponsor: Virginia Department of Behavioral Health and Disability Services

Principal Investigator: Briana Mezuk

Objectives: To update the Virginia state plan for preventing suicide.