Ongoing

 

Strengthening a community-engaged research partnership to promote diabetes self-management in Richmond

Dates: 7/1/16-6/30/17

Sponsor: VCU Council for Community Engagement

Principal Investigator: Briana Mezuk

Objectives: To conduct mixed-methods research on the challenges people face when participating in a diabetes class and the ways they overcome those challenges and to establish a Community Advisory Board.

 

Genetic, social, and developmental epidemiology of drug use disorders

Dates: 4/1/16 – 1/31/21

Sponsor: NIDA (2 R01-DA030005-06A1)

Principle Investigator: Kenneth Kendler

Co-investigator: Briana Mezuk

Objective: To understand the etiology, consequences, and causes of drug use disorders using data available on the entire population of Sweden.

 

Stress, self-regulatory behaviors, and diabetes disparities

Dates: 1/1/2016-12/31/2018

Sponsor: American Diabetes Association (1-16-ICTS-082)

Principal Investigator: Briana Mezuk

Objectives: To examine how stress exposure and stress reactivity contribute to the progression of metabolic risk among adult with pre-diabetes.

 

Depression, inflammation, and diabetes: Exploring shared etiopathology

Date: 8/1/2012 – 7/31/2016

Sponsor: National Institute of Mental Health (K01-MH093642-A1)

Principal Investigator: Briana Mezuk

Mentor: Kenneth Kendler

Objectives: To evaluate environmental and genetic contributions, and their interaction, of the relationship between major depression and type 2 diabetes in later adulthood; investigate the physiologic pathways, particularly immune function, linking depression and diabetes; and examine the influence of depressive symptoms on expression of immune-related genes and glucose metabolism.

 

Reducing ethnic group disparities in cardiovascular and mental health disorders (Project within the Center for Integrative Approaches to Health Disparities)

Date: 8/1/12 – 7/31/17

Sponsor: National Institute on Minority Health and Health Disparities (2P60-MD002249-06)

Principle Investigators: Ana Diez Roux, James S. Jackson

Co-Investigator: Briana Mezuk

Objectives: To examine how stress, poor health behaviors, and mental health contribute to disparities in cardiovascular disease and other conditions using existing data sources.

 

Completed

 

Understanding Health Disparities in the Progression of Type 2 Diabetes

Date: 9/1/2010 – 8/31/2015

Sponsor: National Institute on Minority Health and Health Disparities (R01-MD006085)

Principle Investigator: James S. Jackson

Consultant: Briana Mezuk

Objectives: To examine the interrelationships between stress, health behaviors, and depression in an accelerated longitudinal design by examining these relationships in three progressive groups of type 2 diabetes patients: pre-diabetes, newly onset diabetes; and poorly-controlled diabetes.

 

Frailty and depression: A latent trait analysis

Date: 7/1/13 – 6/30/15

Sponsor: National Institute of Aging (F31-AG044974-01A1)

Principal Investigator: Matthew Lohman

Primary Mentor: Briana Mezuk

Objective: To provide instruction in methodological and conceptual approaches of investigating comorbidity in later life; to provide training in the area of quantitative epidemiologic research; and to conduct mentored independent research on the interrelationships between depression and frailty.

 

Diabetes, depression, and the contextual environment: A multi-level analysis

Date: 3/18/2013 – 2/28/2015

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (R21-DK8356430-01A1)

Principal Investigator: Briana Mezuk

Objectives: To prospectively investigate the dynamic roles of the contextual environment, familial genetic risk, and their interplay on the development of comorbid type 2 diabetes and depression.

 

Stress reactivity and glycemia among African Americans at high risk for type 2 diabetes

Date: 8/1/12 – 12/31/13

Sponsor: AD Williams Fund, VCU Center for Advancing Translational Sciences

Principal Investigator: Briana Mezuk

Objective: To examine the role of stress exposure and biological stress reactivity as predictors of racial disparities in diabetes risk.

 

Examining the interrelationships between depression and metabolic disorders in later life

Date: 7/1/2012 – 6/30/2013

Sponsor: NIH Extramural Clinical Research Loan Repayment Program (Renewal)

Principal Investigator: Briana Mezuk

Mentor: Kenneth Kendler

Objectives: (1) Repayment of educational debt; (2) Research focused on parallel investigators of the epidemiologic links between depression and metabolic conditions in later life.

 

Depression, antidepressants, and frailty

Date: 8/1/2010 – 7/31/2012

Sponsor: National Institute for Child Health and Development, Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar (K12-HD055881)

Principal Investigator: Jerome Strauss

Mentor: Kate Lapane

Fellow: Briana Mezuk

Objectives: To examine the bi-directional relationships between depression and frailty syndrome among older adults; evaluate whether physiologic markers mediate the relationship between depression and frailty; and assess whether antidepressants are associated with frailty independent of depression.

 

Suicide prevention across the lifespan for the Commonwealth of Virginia

Date: 3/1/12 – 7/31/12

Sponsor: Virginia Department of Behavioral Health and Disability Services

Principal Investigator: Briana Mezuk

Objectives: To update the Virginia state plan for preventing suicide.